Human iPSC-derived Cardiomyocytes(iCMs)
Product Overview
The cardiomyocytes are a specialized group of cells that form the muscular tissue of the heart, characterized by their unique striated appearance and the ability to contract autonomously. These cells play a vital role in the cardiovascular system by generating the force necessary for pumping blood throughout the body, maintaining a regular heartbeat, and participating in the electrical conduction system that regulates heart rhythm.
The iCardiomyocytes (iCMs) from iCells International, derived from human iPSCs, are a purified population of research-grade cardiomyocytes with various applications in disease modeling, drug discovery, safety testing, and regenerative medicine.
Available in commercial quantities, iCMs possess several key features that make them ideal for research and therapeutic development:
1. High Purity: Ensuring that the cell population is predominantly cardiomyocytes, which is crucial for accurate experimental results.
2. Functional Maturity: Exhibiting electrophysiological properties and contractile function similar to native cardiomyocytes, allowing for the study of heart function in a controlled environment.
3. Customizability: The ability to derive iCMs from a wide range of donor iPSC lines, enabling the study of genetic diversity and personalized medicine approaches.
4. Scalability: The capacity to produce large quantities of iCMs for high-throughput screening and other large-scale research endeavors.
Biological Source | Human iPSCs |
Disease | Normal |
Growth Mode | Adherent |
Morphology | Shuttle-shaped |
Number of cells | 1×106cells/vial |
Product format | Frozen |
Storage | Vapor phase of liquid nitrogen |
Quality Control | Negative for HIV-1, HBV, HCV,CMV, mycoplasma, bacteria, yeast, and fungi |
Application | Research use only |
Performance Data
1) Cell morphology
High-purity iCMs are obtained by deriving them from hiPSCs
Figure 1: Morphological map of cells at different stages of induced hiPSC differentiation into iCMs in vitro
2）Cell purity
Cell purity greater than 96%
Figure 2: Immunostaining shows the expression of the iCMs markers, cTnT and α-actinin
Figure 3: Flow cytometry shows the expression of iCMs marker cTnT